General Information

  • ID:  hor001224
  • Uniprot ID:  O17058
  • Protein name:  FLP-24
  • Gene name:  flp-24
  • Organism:  Caenorhabditis elegans
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Expressed in the ALA neuron in L4 stage larvae.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  VPSAGDMMVRFG
  • Length:  12(54-65)
  • Propeptide:  MLSSRTSSIILILAILVAIMAVAQCRNIQYDVEEMTPEAAFRYAQWGEIPHKRVPSAGDMMVRFGKRSI
  • Signal peptide:  MLSSRTSSIILILAILVAIMAVAQC
  • Modification:  T11 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Probable FMRFamide-like neuropeptides (PubMed:27546573). Plays a role in behaviors associated with a sleep-like state induced by stress (SIS), acting in concert with the FMRFamide related peptide flp-13 and neuropeptide-like protein nlp-8 (PubMed:27546573
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O17058-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001224_AF2.pdbhor001224_ESM.pdb

Physical Information

Mass: 146288 Formula: C54H87N15O16S2
Absent amino acids: CEHIKLNQTWY Common amino acids: GMV
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: 46.67 Boman Index: -759
Half-Life: 100 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 56.67
Instability Index: 3886.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  17564681
  • Title:  Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.